Fix “Access Denied” on Registry and Filesystem
Today I installed the May CU on a SharePoint 2013 farm hosted in Azure. After the Installation was done (with a PowerShell script that disables some services to speed up the process), there were Exceptions opening the User Profile Service (UPS) settings page.
So I investigated the logs and found many entries about “Access Denied”. Some directly pointed to the registry hive “HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Office Server\15.0” with the message Requested registry access is not allowed.